The article is published as a result of the fruitful collaboration between the EC3R partners. Its authors are Ahmed S.M. Ali, Dongwei Wu, Alexandra Bannach-Brown, Diyal Dhamrait, Johanna Berg, Beatrice Tolksdorf, Dajana Lichtenstein, Corinna Dressler, Albert Braeuning, Jens Kurreck and Maren Hülsemann.

The systematic scoping review offers an evidence-based overview and evaluation of the current state of research on bioprinted liver models, representing a promising and innovative technology for creating alternative organ models.

The Higlights of the article are

• First evidence-based assessment of bioprinted liver models through a systematic scoping review.
• Extrusion-based printing is the predominantly used method in 3D bioprinting of liver models.
• Natural bioinks composed of protein and/or polysaccharide are most widely used in the field.
• HepG2 hepatoma cell line is most frequently employed liver cell type, despite known limitations.
• Identified reporting gaps enable improvements towards higher method reproducibility.

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