Research Stories

Trust is the Key

Organoids are of significant interest due to their frequent portrayal as a potential substitute for animal testing. However, there is currently a lack of uniform, well-established quality standards for these organ models. A project at the Einstein Center 3R aims to change this.

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Artificial heart tissue for functional diagnostics, drug testing and therapy

The aim of the EC3R project "Engineering of human heart tissue for functional diagnostics, drug testing and therapy" is to reproduce heart diseases in a Petri dish. Under the leadership of Prof. Michael Gotthardt and Dr. Sebastian Diecke, the research team is developing artificial heart tissue in order to shed light on disease mechanisms, test drugs and reduce the number of animal experiments in accordance with the 3R principle.

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Mini lungs in the lab

Human lung tissue cultivated in the laboratory helps to better understand respiratory diseases ranging from asthma to pneumonia and enables researchers to find new therapeutics. Moreover, the risk of new pathogens can also be assessed more quickly. 

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Video Clips

Insights into the EC3R through films from the laboratories.

Neuromuscular Junction

Dr. Mina Gouti's group has brought the neuromuscular junction into the Petri dish. With Prof. Dr. Carmen Birchmeier (MDC) and Prof. Dr. Nikolaus Rajewsky (MDC/BIMSB) she is working on the maturation of the…

Bio-Printing

The project group of Prof. Jens Kurreck (TU Berlin), Dr. Johanna Berg (TU Berlin) and Prof. Dr. Albert Braeuning (BfR) deals with the bio-printing of human organ models.

Engineered Heart Tissue

Prof. Michael Gotthardt (MDC/Charité) and Dr. Sebastian Diecke (MDC/BIH) aim to improve clinical therapeutic approaches using disease models.

Human Lung Models and Machine Learning

The Hocke group works with different lung models, e.g. lung tissue or lung organoids. The project at EC3R acts as an imaging and analysis platform.

Podcasts

Deutschlandfunk | "Animal suffering unavoidable? Day of the Laboratory Animal" 24.04.23 (German, 6 mins.)

On the occasion of 24 April, the Day of the Laboratory Animal, Prof. Dr. Stefan Hippenstiel (Charité - Universitätsklinikum Berlin, Charité 3R) gave an interview on Deutschlandfunk for the resort "Umwelt & Verbaucher".

Listen to the complete interview from 24.04.2023 here.

BR50 Podcast | "Animal Testing in Berlin - In Search of Alternatives" 24.04.22 (German, 45 mins.)

Please note that this podcast is in German.

In the fourth BR50 podcast episode "Animal Testing in Berlin - In Search of Alternatives", moderated by science journalist Thomas Prinzler, the biotechnologist Julia Scheinpflug (Bf3R), Prof. Dr. Christa Thöne-Reineke (FU Berlin, EC3R) and Prof. Dr. Michael Gotthardt (MDC, EC3R) come together and discuss.

To the BR50 podcast episode #4 (duration approx. 45 min)

What is the BR50 Podcast?

Berlin Research 50 (BR50) is an initiative of Berlin's non-university research institutions that launched this podcast on the occasion of the Day of the Laboratory Animal on April 24, 2022.

BR50 includes the Helmholtz, Leibniz, and Max Planck Institutes, as well as the federal government's departmental research and other non-university research institutes in Berlin.

The BR50 podcast offers a science policy discussion format and highlights one exciting topic per episode, on which two to three scientists discuss controversial issues. The conversations are moderated alternately by Nancy Fischer and Thomas Prinzler. 

RadioWissen of Bayern 2 | "Animal Testing - Still Indispensable?", 01.10.21 (German, 20 mins.)

Please note that this podcast is in German.

This podcast from 01.10.2021 is about the framework conditions of animal experiments and the 3R principle. Prof. Christa Thöne-Reineke and Prof. Stefan Hippenstiel (both EC3R) as well as Prof. Sina Bartfeld have their say.

Listen to the full podcast here

NDR-Info Science Podcast "Synapsen" | "On the Value of Animals" 24.09.21 (German, 60 mins.)

Please note that this podcast is in German.

The science podcast "Synapsen" takes a multi-layered look at the topic of animal experiments and our relationship to animals. Prof. Michael Gotthardt from the MDC gives voice to the Einstein Center 3R.

Listen to the full podcast from 24.09.2021 here.

The podcast Synapses has published a second part on the topic under the title "Replace, Reduce, Refine" on 04.03.2022.

Deutschlandfunk | "Research without animal experiments", 16.09.21 (German, 5mins.)

Deutschlandfunk | "Research without animal experiments" 

For the Deutschlandfunk programme Campus & Karriere, Prof. Stefan Hippenstiel was interviewed on the topic of "Research without animal experiments". He talked about his experiences in research on pneumonia and about the Einstein Centre 3R.

Listen to the complete interview from 16.09.2021 here.