Three-dimensional (3D) tissue culture models have been the subject of research for more than ten years. They are considered an important methodological breakthrough in modern biomedicine and have the potential to contribute significantly to the implementation of the 3Rs principle. Increasing evidence suggests that (human) 3D tissue models can better reflect human biology than traditional 2D culture models and at least some animal models.
However, what is evident is that there is a significant need for research to describe the limitations and capabilities of the models and thus make them more useful for research in 3Rs and biomedicine as a whole.
The goal of the Einstein Center 3R is therefore to create robust models that provide reproducible results across laboratories.
Study of spatiotemporal epithelial-niche interplay in 3D intestinal organoids to improve standardization & reproducibility
A perfusable xeno-free human microvasculature-on-a-chip model to study vascular physiology and disease
Enhancing the maturation of complex human neuromuscular organoids for personalized medicine approaches
3D bioprinting of human organ models
Cross-species comparability and validity of disease models
6R - robustness, registration, reporting of 3R projects
