EC3R research

Three-dimensional (3D) tissue culture models have been the subject of research for about ten years. They are considered an important methodological breakthrough in modern biomedicine and have the potential to contribute significantly to the implementation of the 3Rs principle. Increasing evidence suggests that (human) 3D tissue models can better reflect human biology than traditional 2D culture models and at least some animal models.

However, what is evident is that there is a significant need for research to describe the limitations and capabilities of the models and thus make them more useful for research in 3Rs and biomedicine as a whole.

The goal of the Einstein Center 3R is therefore to create robust models that provide reproducible results across laboratories.

"Study of spatiotemporal epithelial-niche interplay in 3D intestinal organoids to improve standardization & reproducibility"

The project of Dr. Michael Sigal (Charité), Prof. Dr. Britta Siegmund (Charité) and Prof. Jens Kurreck (TU Berlin) investigates specific parameters that influence the formation and growth of intestinal…

"Engineering human heart tissue for functional diagnosis, drug testing, and therapy"

In the project of Prof. Michael Gotthardt (MDC/Charité), Dr. Sebastian Diecke (MDC/BIH) and Prof. Burkert Pieske (Charité), clinicians and basic scientists are working together. Their goal is to facilitate the…

"Modelling cross-body organ dysfunction using human brain organoids to investigate neurodegenerative diseases"

In their project, Dr. Philipp Mergenthaler (Charité/BIH), Dr. Harald Stachelscheid (Charité/BIH) and Prof. Dr. Andreas Meisel (Charité) are focusing on the influence of mechanisms of the immune system on the…

"Human lung organoids for biomedical research as alternatives to animal models"

The project of Dr. Mirjana Kessler (Charité) and Dr. Katja Hönzke (Charité) aims to further develop the lung model, which currently consists mainly of epithelial cells. The expansion of the model with further…

"Enhancing the maturation of complex human neuromuscular organoids for personalized medicine approaches"

Growing two or more different tissues in a single functional organoid is a special challenge that Gouti-Lab has mastered with the generation of neuromuscular organoids. Such organoids enable the study of…

"3D bioprinting of human organ models"

The method-centered project of Prof. Jens Kurreck (TU Berlin), Dr. Johanna Berg (TU Berlin) and Prof. Dr. Albert Braeuning (BfR) offers within the Einstein Center the opportunity to produce human organ models…

"Cross-species comparability and validity of disease models"

This project by Prof. Dr. Andreas Hocke (Charité) and Prof. Dr. Achim Gruber (FU Berlin) acts as an imaging and analysis platform. In this, the cross-species comparability and informative value of disease…

"6R - robustness, registration, reporting of 3R projects"

The aim of the project by Prof. Dr. Ulrich Dirnagl (BIH), Dr. Ulf Tölch (BIH) and Prof. Dr. Daniel Strech (BIH) is to improve the quality of the models by creating a framework of measures and principles valid…

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