Regenerative potential of the human lung, especially the cellular mechanisms that control epithelial renewal of the alveolar compartment, remain incompletely understood. Due to its central importance for the respiratory function of the organ, necessity to advance our knowledge in this research field has far-reaching implications. The team of Enstein 3R Center scientists, led by Dr. Mirjana Kessler, achieved important progress in understanding the differentiation plasticity of the alveolar progenitors. By combining sc-RNA analysis of the epithelial cells from the native adult lung tissue, and controlled in vitro differentiation and phenotypic characterization of the organoids, they could demonstrate that alveolar progenitors can give rise to both alveolar and airway cell types. New study, published in Open Access journal, Communications Biology, underlies importance of the local signalling environment and reveals novel aspects of lung biology that need to be considered in the research of pneumonia and chronic lung diseases.
- Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Commun Biol. 2022 Aug 25;5(1):875.
PMID: 36008580 DOI: 10.1038/s42003-022-03828-5