Charité 3R cordially invites you to a lecture exploring neuroinflammation mechanisms underlying neurodegeneration and opportunities for drug discovery, with models from mouse to human.
- Speakers & Topics
Róisín McManus - “Microglial innate immune signalling as a driver of dementia”
Camin Dean - “A human neuron-astrocyte network for dementia drug discovery” - Venue: Charité Campus Mitte, Virchowweg 24, ground floor, Konrad-Cohn lecture hall
- REGISTER HERE until 08.01.2026!
- More information: here
After the lectures, there will be the opportunity to discuss with both speakers in a get-together from 5:30 pm on.
Róisín McManus will also be available for 1:1 meetings the day after, 14th of January, 9 – 12 am. If you are interested, please let us know: c3r-research(at)charite.de.
About the speakers
Róisín McManus (PhD) Head of the Translational Neuroimmunology Research Group, German Center for Neurodegenerative Diseases (DZNE), Bonn
Following on from her postdocs with Michael T Heneka and then Eicke Latz, McManus’ Research Group examines how innate immune signaling in microglia changes with aging and disease, including how NLRP3 inflammasome activation alters microglial metabolism, inflammation, and clearance of pathological proteins, as recently published in Immunity. This offers insights into mechanisms and therapeutic targets in neurodegeneration. She combines murine and human models for optimal translation.
Camin Dean (PhD) Head of the Synaptic Dysfunction Research Group, German Center for Neurodegenerative Diseases (DZNE), Berlin
Camin Dean studies how synapses strengthen or weaken in response to neuronal activity and how these changes contribute to memory loss and neurodegeneration. Using brain slices and hIPSC-derived neuron–astrocyte networks, her team investigates molecular regulators of synapse stability, plasticity and network function to discover treatments to support memory and counter neurodegeneration.