- Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin M, Hartl K, Heuberger J, Beccaceci G, Berger H, Li H, Liu L, Müllerke S, Conrad T, Heymann F, Woehler A, Tacke F, Rajewsky N, Sigal M.
Nat Commun. 2023;14(1):3025. Published 2023 May 25.
PMID: 37230989 DOI: 10.1038/s41467-023-38780-3
- Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo.
Parshad B, Schlecht MN, Baumgardt M, Ludwig K, Nie C, Rimondi A, Hönzke K, Angioletti-Uberti S, Khatri V, Schneider P, Herrmann A, Haag R, Hocke AC, Wolff T, Bhatia S.
Nano Lett. 2023;23(11):4844-4853.
PMID: 37220024 DOI: 10.1021/acs.nanolett.3c00408
- Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L.
Antiviral Res. 2023 Jan;209:105475.
PMID: 36423831 DOI: 10.1016/j.antiviral.2022.105475
- State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt M, Hülsemann M, Löwa A, Fatykhova D, Hoffmann K, Kessler M, Mieth M, Hellwig K, Frey D, Langenhagen A, Voss A, Obermayer B, Wyler E, Dökel S, Gruber AD, Tölch U, Hippenstiel S, Hocke AC, Hönzke K.
PLoS One. 2022 Dec 20;17(12):e0276115.
PMID: 36538516 DOI: 10.1371/journal.pone.0276115
- Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus.
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC.
Sci Rep. 2022 Nov 29;12(1):20608.
PMID: 36446841 DOI: 10.1038/s41598-022-24792-4
- SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C.
PLoS Biol. 2022 Nov 16;20(11):e3001871.
PMID: 36383605 DOI: 10.1371/journal.pbio.3001871
- R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer AS, Müllerke S, Arnold A, Heuberger J, Berger H, Lin M, Mollenkopf HJ, Wizenty J, Horst D, Tacke F, Sigal M.
J Clin Invest. 2022;132(21):e151363. Published 2022 Nov 1.
PMID: 36099044 DOI:10.1172/JCI151363
- Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Commun Biol. 2022 Aug 25;5(1):875.
PMID: 36008580 DOI: 10.1038/s42003-022-03828-5
- Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research.
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
EMBO Rep. 2022 Aug 3;23(8):e55095.
PMID: 35876564 DOI: 10.15252/embr.20225509
- A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
Eur Respir Rev. 2022 Jul 27;31(165):220056.
PMID: 35896273 DOI: 10.1183/16000617.0056-2022
- Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty J, Müllerke S, Kolesnichenko M, Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F, Sigal M.
EMBO J. 2022, June 29; 41(13):e109996.
PMID: 35767364 DOI:10.15252/embj.2021109996
- Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.
Eur Respir J. 2022 Jun 21:2102725.
PMID: 35728978 DOI: 10.1183/13993003.02725-2021
- A Systematic Scoping Review on 3D Printing Technologies of Liver Organ Models.
Huelsemann M, Ali A S M , Berg J, Bannach-Brown A, Dressler C, Dhamrait D, Khankeh S, Toelch U, Braeuning A, Kurreck J.
2022, June 3
DOI: 10.17605/OSF.IO/WMY3X
- The Rise of Three Rs Centres and Platforms in Europe.
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H.
Altern Lab Anim. 2022 Mar;50(2):90-120.
PMID: 35578444 DOI: 10.1177/02611929221099165
