2025
- SARS-CoV-2 infection of human lung ALI cultures reveals basal cells as relevant target
Baumgardt M, Obermayer B, Balázs A, Löwa A, Wyler E, Teixeira Alves LG, Hellwig K, Beule D, Landthaler M, Müller MA, Drosten C, Mall MA, Hippenstiel S, Hönzke K, Hocke AC
J Infect Dis. 2025 PMID: 40065723 | Open access
- Xeno-Free 3D Bioprinted Liver Model for Hepatotoxicity Assessment.
Ali AS, Berg J, Roehrs V, Wu D, Hackethal J, Braeuning A, Woelken L, Rauh C, Kurreck J.
Int J Mol Sci. 2024. PMID: 38339088 | Open access
- 3D bioprinting of liver models: A systematic scoping review of methods, bioinks, and reporting quality.
Ali AS, Wu D, Bannach-Brown A, Dhamrait D, Berg J, Tolksdorf B, Lichtenstein D, Dressler C, Braeuning A, Kurreck J, Hülsemann M.
Mater Today Bio. 2024. PMID: 38558773 | Open access
- 2-Deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat.
Boehm-Sturm P, Schuenke P, Foddis M, Mueller S, Koch SP, Beard DJ, Holloway P, Mottahedin A, Schröder L, Buchan AM, Mergenthaler P.
bioRxiv. 2025; doi: 10.1101/2025.01.08.628135. preprint, under review.
- Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.
Bolduan F, Wetzel A, Giesecke Y, Eichhorn I, Alenina N, Bader M, Willnow TE, Wiedenmann B, Sigal M.
Front Endocrinol (Lausanne). 2024. PMID: 38694940 | Open access
- Simultaneous Lung Cell and Nucleus Segmentation From Labelled Versus Unlabelled Human Lung DIC Images.
Dohmen M, Mittermaier M, Rumberger JL, Yang LL, Gruber AD, Toennies M, Hippenstiel S, Kainmueller D, Hocke AC.
IEEE International Symposium on Biomedical Imaging (ISBI). 2024 May, doi: 10.1109/ISBI56570.2024.10635198
- Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova D, Fritsch VN, Siebert K, Methling K, Lalk M, Busche T, Kalinowski J, Weiner J, Beule D, Bertrams W, Kohler TP, Hammerschmidt S, Löwa A, Fischer M, Mieth M, Hellwig K, Frey D, Neudecker J, Rueckert JC, Toennies M, Bauer TT, Graff M, Tran HL, Eggeling S, Gruber AD, Antelmann H, Hippenstiel S, Hocke AC.
Eur Respir J. 2024. PMID: 39231629 | Open access
- Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets.
Halwe NJ, Hamberger L, Sehl-Ewert J, Mache C, Schön J, Ulrich L, Calvelage S, Tönnies M, Fuchs J, Bandawane P, Loganathan M, Abbad A, Carreño JM, Bermúdez-González MC, Simon V, Kandeil A, El-Shesheny R, Ali MA, Kayali G, Budt M, Hippenstiel S, Hocke AC, Krammer F, Wolff T, Schwemmle M, Ciminski K, Hoffmann D, Beer M.
Nat Commun. 2024. PMID: 38664395 | Open access
- p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl K, Bayram Ş, Wetzel A, Harnack C, Lin M, Fischer AS, Liu L, Beccaceci G, Mastrobuoni G, Geisberger S, Forbes M, Monteiro BJE, Macino M, Flores RE, Engelmann C, Mollenkopf HJ, Schupp M, Tacke F, Sanders AD, Kempa S, Berger H, Sigal M.
Sci Adv. 2024. PMID 39453996 | Open access
- Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase 2 Probes Enable Translational Research.
Hentsch A, Guberman M, Radetzki S, Kaushik S, Huizenga M, He Y, Contzen J, Kuhn B, Benz J, Schippers M, Paul J, Leibrock L, Collin L, Wittwer M, Topp A, O'Hara F, Heer D, Hochstrasser R, Blaising J, P von Kries JP, Mu L, van der Stelt M, Mergenthaler P, Lipstein N, Grether U, Nazaré M.
J Am Chem Soc. 2025. PMID: 40063733 | Open access
- Three-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research.
Mei Y, Lakotsenina E, Wegner M, Hehne T, Krause D, Hakimeh D, Wu D, Schültke E, Hausmann F, Kurreck J, Tolksdorf B.
Int. J. Mol. Sci. 2024. PMID: 39408596 | Open access
- Universal quasi-particle kinetics control the cell death decision.
Meigel F, Hellwig L, Stachelscheid H, Mergenthaler P, Ruland S.
arXiv. 2025; doi: 10.48550/arXiv.2501.04862. preprint, under review.
- SARS-CoV-2 tropism to intestinal but not gastric epithelial cells is defined by limited ACE2 expression.
Paužuolis M, Fatykhova D, Zühlke B, Schwecke T, Neyazi M, Samperio-Ventayol P, Aguilar C, Schlegel N, Dökel S, Ralser M, Hocke A, Krempl C, Bartfeld S.
Stem Cell Reports. 2024. PMID: 38670110 | Open access
- Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters.
Teixeira Alves LG, Baumgardt M, Langner C, Fischer M, Maria Adler J, Bushe J, Firsching TC, Mastrobuoni G, Grobe J, Hoenzke K, Kempa S, Gruber AD, Hocke AC, Trimpert J, Wyler E, Landthaler M.
BMJ Open Respir Res. 2024. PMID: 38423952 | Open access
- Bioprinting of Perfusable Vascularized Organ Models for Drug Development via Sacrificial-free Direct Ink Writing.
Wu D, Pang S, Berg J, Mei Y, Ali AS, Röhrs V, Tolksdorf B, Hagenbuchner J, Ausserlechner MJ, Deubzer HE, Gurlo A, Kurreck J.
Adv. Funct. Mater 34, 2314171, 2024. | https://doi.org/10.1002/adfm.202314171
- Man vs. Machine: Automated Bioink Mixing Device Improves Reliability and Reproducibility of Bioprinting Results even Compared to Skilled Human Operators.
Wu D, Pang S, Roehrs V, Berg J, Ali AS, Mei Y, Ziersch M, Tolksdorf B, Kurreck J.
Int. J. Bioprint. 10, 380, 2024. | doi.org/10.36922/ijb.1974
- Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L. V. N., Rost, B. R., García-Pérez, A., Lelievre, N., Merritt-Garza, M. E., Phan, H. C., Bassell, G. J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D., & Gouti, M.
Nat Commun. 2023;14(1):8043. Published 2023 Dec 19.
PMID: 38114482 PMCID: PMC10730704 DOI: 10.1038/s41467-023-43781-3
- Association of Helicobacter pylori Positivity With Risk of Disease and Mortality
Wizenty, J., Koop, P. H., Clusmann, J., Tacke, F., Trautwein, C., Schneider, K. M., Sigal, M., & Schneider, C. V.
Clinical and translational gastroenterology, 2023 Sept. 1
PMID: 37367296 DOI: 10.14309/ctg.0000000000000610
- Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Nouailles G, Adler JM, Pennitz P, Peidli S, Teixeira Alves LG, Baumgardt M, Bushe J, Voss A, Langenhagen A, Langner C, Martin Vidal R, Pott F, Kazmierski J, Ebenig A, Lange MV, Mühlebach MD, Goekeri C, Simmons S, Xing N, Abdelgawad A, Herwig S, Cichon G, Niemeyer D, Drosten C, Goffinet C, Landthaler M, Blüthgen N, Wu H, Witzenrath M, Gruber AD, Praktiknjo SD, Osterrieder N, Wyler E, Kunec D, Trimpert J.
Nat Microbiol. 2023 May.
PMID: 37012419 DOI: 10.1038/s41564-023-01352-8
- Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin M, Hartl K, Heuberger J, Beccaceci G, Berger H, Li H, Liu L, Müllerke S, Conrad T, Heymann F, Woehler A, Tacke F, Rajewsky N, Sigal M.
Nat Commun. 2023;14(1):3025. Published 2023 May 25.
PMID: 37230989 DOI: 10.1038/s41467-023-38780-3
- Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo.
Parshad B, Schlecht MN, Baumgardt M, Ludwig K, Nie C, Rimondi A, Hönzke K, Angioletti-Uberti S, Khatri V, Schneider P, Herrmann A, Haag R, Hocke AC, Wolff T, Bhatia S.
Nano Lett. 2023;23(11):4844-4853.
PMID: 37220024 DOI: 10.1021/acs.nanolett.3c00408
- Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L.
Antiviral Res. 2023 Jan;209:105475.
PMID: 36423831 DOI: 10.1016/j.antiviral.2022.105475
- State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt M, Hülsemann M, Löwa A, Fatykhova D, Hoffmann K, Kessler M, Mieth M, Hellwig K, Frey D, Langenhagen A, Voss A, Obermayer B, Wyler E, Dökel S, Gruber AD, Tölch U, Hippenstiel S, Hocke AC, Hönzke K.
PLoS One. 2022 Dec 20;17(12):e0276115.
PMID: 36538516 DOI: 10.1371/journal.pone.0276115
- Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus.
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC.
Sci Rep. 2022 Nov 29;12(1):20608.
PMID: 36446841 DOI: 10.1038/s41598-022-24792-4
- SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C.
PLoS Biol. 2022 Nov 16;20(11):e3001871.
PMID: 36383605 DOI: 10.1371/journal.pbio.3001871
- R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer AS, Müllerke S, Arnold A, Heuberger J, Berger H, Lin M, Mollenkopf HJ, Wizenty J, Horst D, Tacke F, Sigal M.
J Clin Invest. 2022;132(21):e151363. Published 2022 Nov 1.
PMID: 36099044 DOI:10.1172/JCI151363
- Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Commun Biol. 2022 Aug 25;5(1):875.
PMID: 36008580 DOI: 10.1038/s42003-022-03828-5
- Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research.
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
EMBO Rep. 2022 Aug 3;23(8):e55095.
PMID: 35876564 DOI: 10.15252/embr.20225509
- A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
Eur Respir Rev. 2022 Jul 27;31(165):220056.
PMID: 35896273 DOI: 10.1183/16000617.0056-2022
- Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty J, Müllerke S, Kolesnichenko M, Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F, Sigal M.
EMBO J. 2022, June 29; 41(13):e109996.
PMID: 35767364 DOI:10.15252/embj.2021109996
- Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.
Eur Respir J. 2022 Jun 21:2102725.
PMID: 35728978 DOI: 10.1183/13993003.02725-2021
- A Systematic Scoping Review on 3D Printing Technologies of Liver Organ Models.
Huelsemann M, Ali A S M , Berg J, Bannach-Brown A, Dressler C, Dhamrait D, Khankeh S, Toelch U, Braeuning A, Kurreck J.
2022, June 3
DOI: 10.17605/OSF.IO/WMY3X
- The Rise of Three Rs Centres and Platforms in Europe.
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H.
Altern Lab Anim. 2022 Mar;50(2):90-120.
PMID: 35578444 DOI: 10.1177/02611929221099165
