2026
- Clade 2.3.4.4b H5N1 influenza A virus exhibits high infectivity in human respiratory tract models
Löwa A, Budt M, Balázs A, Sikora V, Melzer M, Rubil T, Pfeiffer AE, Fischer M, Mieth M, Hellwig K, Wyler E, Diel DG, Tönnies M, Bauer TT, Graff M, Neudecker J, Rückert JC, Mall MA, Gruber AD, Landthaler M, Buchauer L, Hippenstiel S, Wolff T, Hocke AC
J Infect. 2026 Mar 12. PMID: 41831654 | Open access
- Lung tumouroids as a testing platform for precision CAR T cell therapy
Ehlen L, Farrera-Sal M, Szyska M, Arndt J, Schallenberg S, Scholz C, Yang M, Vollbrecht C, Löwa A, Friedrich R, Mai M, Peter L, Picht S, Schulenberg S, Geray D, Korus G, Sommerfeld A, Treue D, Strauchmann J, Elsner A, Kath J, Vallone VF, Joosten M, Klatte-Schulz F, Petersen A, Stachelscheid H, Wagner DL, Spies C, Rückert JC, Hocke AC, Polansky JK, Stark R, Klein O, Schmueck-Henneresse M
Nat Biomed Eng. 2026 Jan 21. PMID: 41565786 | Open access
- 2-Deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat.
Boehm-Sturm P, Schuenke P, Foddis M, Mueller S, Koch SP, Beard DJ, Holloway P, Mottahedin A, Schröder L, Buchan AM, Mergenthaler P.
J Cereb Blood Flow Metab. .2025 Dec. PMID: 40626496 | Open access
- 3D-Biodruck perfundierbarer Krebsmodelle
Wu D, Kurreck J.
Biospektrum.2025 Nov 22 | Open acces
- Liver-on-Micropillar: a humanized, animal-free platform for high-throughput assessment of drug-induced liver injury
Ali ASM, Wu D, Roehrs V, Nguyen DBT, Ziersch M, Braeuning A, Kurreck J.
Biofabrication. 2025 Oct 23. PMID: 41056958 | Open access
- Promoting ethical and reproducible cell culture: implementing animal-free alternatives to teaching in molecular and cell biology
Nessar A, Röhrs V, Ziersch M, Ali ASM, Moradi J, Kurreck A, Berg J, Kurreck J.
Front Toxicol. 2025 Oct 1. PMID: 41104013 | Open access
- Ten quick tips for navigating intellectual property in FAIR educational resources
Funk EM, Toelch U, Ludwig R, Kniffert S.
PLoS Comput Biol. 2025 Jul 8. PMID: 40627613 | Open access
- Strong correlation of gene counts and differentially expressed genes between a 3′ RNA-Seq and an RNA hybridization platform in transcriptome analyses from canine archival tissues
Haake A, Loriani Fard AK, Jovanovic V, Sandro A, Gruber AD
Front. Vet. Sci. 2025 Jun 30. PMID: 40661172 | Open access
- Bioprinted Four-Cell-Type Lung Model for Viral Infection Studies Under Air–Liquid Interface Conditions
Berg J, Heinze J, Niemeyer D, Hellgren J, Jaiswal H, Löwa A, Hocke AC, Namro I, Drosten C, Kurreck J, Tolksdorf B
Int. J. Mol. Sci. 2025 Jun 10.PMID: 40565011 | Open access
- SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant Targets
Baumgardt M, Obermayer B, Balázs A, Löwa A, Wyler E, Teixeira Alves LG, Hellwig K, Beule D, Landthaler M, Müller MA, Drosten C, Mall MA, Hippenstiel S, Hönzke K, Hocke AC.
J Infect Dis. 2025 Jun 2. PMID: 40065723 | Open access
- Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration
Heuberger J, Liu L, Berger H, van den Heuvel J, Lin M, Müllerke S, Bayram S, Beccaceci G, de Jonge H, Gherardi E, Sigal M.
Nat Commun. 2025 May 3. PMID: 40319019 | Open access
- Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase 2 Probes Enable Translational Research.
Hentsch A, Guberman M, Radetzki S, Kaushik S, Huizenga M, He Y, Contzen J, Kuhn B, Benz J, Schippers M, Paul J, Leibrock L, Collin L, Wittwer M, Topp A, O'Hara F, Heer D, Hochstrasser R, Blaising J, P von Kries JP, Mu L, van der Stelt M, Mergenthaler P, Lipstein N, Grether U, Nazaré M.
J Am Chem Soc. 2025 Mar 26. PMID: 40063733 | Open access
- Microenvironmental acidification by pneumococcal sugar consumption fosters barrier disruption and immune suppression in the human alveolus.
Fatykhova D, Fritsch VN, Siebert K, Methling K, Lalk M, Busche T, Kalinowski J, Weiner J, Beule D, Bertrams W, Kohler TP, Hammerschmidt S, Löwa A, Fischer M, Mieth M, Hellwig K, Frey D, Neudecker J, Rueckert JC, Toennies M, Bauer TT, Graff M, Tran HL, Eggeling S, Gruber AD, Antelmann H, Hippenstiel S, Hocke AC.
Eur Respir J. 2024 Dec 12. PMID: 39231629 | Open access
- p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl K, Bayram Ş, Wetzel A, Harnack C, Lin M, Fischer AS, Liu L, Beccaceci G, Mastrobuoni G, Geisberger S, Forbes M, Monteiro BJE, Macino M, Flores RE, Engelmann C, Mollenkopf HJ, Schupp M, Tacke F, Sanders AD, Kempa S, Berger H, Sigal M.
Sci Adv. 2024 Oct 25. PMID 39453996 | Open access
- Three-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research.
Mei Y, Lakotsenina E, Wegner M, Hehne T, Krause D, Hakimeh D, Wu D, Schültke E, Hausmann F, Kurreck J, Tolksdorf B.
Int. J. Mol. Sci. 2024 Sep 24. PMID: 39408596 | Open access
- Simultaneous Lung Cell and Nucleus Segmentation From Labelled Versus Unlabelled Human Lung DIC Images.
Dohmen M, Mittermaier M, Rumberger JL, Yang LL, Gruber AD, Toennies M, Hippenstiel S, Kainmueller D, Hocke AC.
IEEE International Symposium on Biomedical Imaging (ISBI). 2024 May, doi: 10.1109/ISBI56570.2024.10635198
- Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets.
Halwe NJ, Hamberger L, Sehl-Ewert J, Mache C, Schön J, Ulrich L, Calvelage S, Tönnies M, Fuchs J, Bandawane P, Loganathan M, Abbad A, Carreño JM, Bermúdez-González MC, Simon V, Kandeil A, El-Shesheny R, Ali MA, Kayali G, Budt M, Hippenstiel S, Hocke AC, Krammer F, Wolff T, Schwemmle M, Ciminski K, Hoffmann D, Beer M.
Nat Commun. 2024 Apr 25. PMID: 38664395 | Open access
- SARS-CoV-2 tropism to intestinal but not gastric epithelial cells is defined by limited ACE2 expression.
Paužuolis M, Fatykhova D, Zühlke B, Schwecke T, Neyazi M, Samperio-Ventayol P, Aguilar C, Schlegel N, Dökel S, Ralser M, Hocke A, Krempl C, Bartfeld S.
Stem Cell Reports. 2024 Apr 25. PMID: 38670110 | Open access
- Bioprinting of Perfusable Vascularized Organ Models for Drug Development via Sacrificial-free Direct Ink Writing.
Wu D, Pang S, Berg J, Mei Y, Ali AS, Röhrs V, Tolksdorf B, Hagenbuchner J, Ausserlechner MJ, Deubzer HE, Gurlo A, Kurreck J.
Adv. Funct. Mater 34, 2314171, 2024 March 29 | https://doi.org/10.1002/adfm.202314171
- Protective role of the HSP90 inhibitor, STA-9090, in lungs of SARS-CoV-2-infected Syrian golden hamsters.
Teixeira Alves LG, Baumgardt M, Langner C, Fischer M, Maria Adler J, Bushe J, Firsching TC, Mastrobuoni G, Grobe J, Hoenzke K, Kempa S, Gruber AD, Hocke AC, Trimpert J, Wyler E, Landthaler M.
BMJ Open Respir Res. 2024 Feb 29. PMID: 38423952 | Open access
- 3D bioprinting of liver models: A systematic scoping review of methods, bioinks, and reporting quality.
Ali AS, Wu D, Bannach-Brown A, Dhamrait D, Berg J, Tolksdorf B, Lichtenstein D, Dressler C, Braeuning A, Kurreck J, Hülsemann M.
Mater Today Bio. 2024 Feb 15. PMID: 38558773 | Open access
- Man vs. Machine: Automated Bioink Mixing Device Improves Reliability and Reproducibility of Bioprinting Results even Compared to Skilled Human Operators.
Wu D, Pang S, Roehrs V, Berg J, Ali AS, Mei Y, Ziersch M, Tolksdorf B, Kurreck J.
Int. J. Bioprint. 10, 380, 2024 Feb 12 | https://doi.org/10.36922/ijb.1974 | Open access
- Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L. V. N., Rost, B. R., García-Pérez, A., Lelievre, N., Merritt-Garza, M. E., Phan, H. C., Bassell, G. J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D., & Gouti, M.
Nat Commun. 2023. 2023 Dec 19. PMID: 38114482 | Open access
- Association of Helicobacter pylori Positivity With Risk of Disease and Mortality
Wizenty, J., Koop, P. H., Clusmann, J., Tacke, F., Trautwein, C., Schneider, K. M., Sigal, M., & Schneider, C. V.
Clinical and translational gastroenterology, 2023 Sept. 1. PMID: 37367296 | Open access
- Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin M, Hartl K, Heuberger J, Beccaceci G, Berger H, Li H, Liu L, Müllerke S, Conrad T, Heymann F, Woehler A, Tacke F, Rajewsky N, Sigal M.
Nat Commun. 2023 May 25. PMID: 37230989 | Open access
- Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo.
Parshad B, Schlecht MN, Baumgardt M, Ludwig K, Nie C, Rimondi A, Hönzke K, Angioletti-Uberti S, Khatri V, Schneider P, Herrmann A, Haag R, Hocke AC, Wolff T, Bhatia S.
Nano Lett. 2023 May 23. PMID: 37220024
- Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Nouailles G, Adler JM, Pennitz P, Peidli S, Teixeira Alves LG, Baumgardt M, Bushe J, Voss A, Langenhagen A, Langner C, Martin Vidal R, Pott F, Kazmierski J, Ebenig A, Lange MV, Mühlebach MD, Goekeri C, Simmons S, Xing N, Abdelgawad A, Herwig S, Cichon G, Niemeyer D, Drosten C, Goffinet C, Landthaler M, Blüthgen N, Wu H, Witzenrath M, Gruber AD, Praktiknjo SD, Osterrieder N, Wyler E, Kunec D, Trimpert J.
Nat Microbiol. 2023 Apr 3. PMID: 37012419 | Open access
- Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L.
Antiviral Res. 2023 Jan; PMID: 36423831 | Open access
- State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt M, Hülsemann M, Löwa A, Fatykhova D, Hoffmann K, Kessler M, Mieth M, Hellwig K, Frey D, Langenhagen A, Voss A, Obermayer B, Wyler E, Dökel S, Gruber AD, Tölch U, Hippenstiel S, Hocke AC, Hönzke K.
PLoS One. 2022 Dec 20; PMID: 36538516 | Open Access
- Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus.
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC.
Sci Rep. 2022 Nov 29; PMID: 36446841 | Open Access
- SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C.
PLoS Biol. 2022 Nov 16; PMID: 36383605 | Open Access
- R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer AS, Müllerke S, Arnold A, Heuberger J, Berger H, Lin M, Mollenkopf HJ, Wizenty J, Horst D, Tacke F, Sigal M.
J Clin Invest. 2022 Nov 1. PMID: 36099044 | Open Access
- Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Commun Biol. 2022 Aug 25. PMID: 36008580 | Open Access
- Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research.
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
EMBO Rep. 2022 Aug 3; PMID: 35876564 | Open Access
- A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
Eur Respir Rev. 2022 Jul 27. PMID: 35896273 | Open Access
- Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty J, Müllerke S, Kolesnichenko M, Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F, Sigal M.
EMBO J. 2022, June 29. PMID: 35767364 | Open Access
- Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.
Eur Respir J. 2022 Jun 21. PMID: 35728978 | Open Access
- A Systematic Scoping Review on 3D Printing Technologies of Liver Organ Models.
Huelsemann M, Ali A S M , Berg J, Bannach-Brown A, Dressler C, Dhamrait D, Khankeh S, Toelch U, Braeuning A, Kurreck J.
2022, June 3. DOI: 10.17605/OSF.IO/WMY3X
- The Rise of Three Rs Centres and Platforms in Europe
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H.
Altern Lab Anim. 2022 Mar. PMID: 35578444
