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Publikationen mit Beteiligung des Einstein-Zentrum 3R

p53 terminates the regenerative fetal-like state after colitis-associated injury
Hartl K, Bayram Ş, Wetzel A, Harnack C, Lin M, Fischer AS, Liu L, Beccaceci G, Mastrobuoni G, Geisberger S, Forbes M, Monteiro BJE, Macino M, Flores RE, Engelmann C, Mollenkopf HJ, Schupp M, Tacke F, Sanders AD, Kempa S, Berger H, Sigal M.
Sci Adv. 2024 Oct 25;10(43):eadp8783. Epub 2024 Oct 25.
PMID: 39453996 PMCID: PMC11506124 DOI: 10.1126/sciadv.adp8783

Three-Dimensional-Bioprinted Non-Small Cell Lung Cancer Models in a Mouse Phantom for Radiotherapy Research
Mei Y, Lakotsenina E, Wegner M, Hehne T, Krause D, Hakimeh D, Wu D, Schültke E, Hausmann F, Kurreck J, Tolksdorf B.
Int J Mol Sci. 2024 Sep 24;25(19):10268.
PMID: 39408596; PMCID: PMC11476964; DOI: 10.3390/ijms251910268

3D bioprinting of liver models: A systematic scoping review of methods, bioinks, and reporting quality
Ali ASM, Wu D, Bannach-Brown A, Dhamrait D, Berg J, Tolksdorf B, Lichtenstein D, Dressler C, Braeuning A, Kurreck J, Hülsemann M.
Mater Today Bio. 2024 Feb 15;26:100991.
PMID: 38558773 PMCID: PMC10978534 DOI: 10.1016/j.mtbio.2024.100991

Xeno-Free 3D Bioprinted Liver Model for Hepatotoxicity Assessment
Ali, A. S. M., Berg, J., Roehrs, V., Wu, D., Hackethal, J., Braeuning, A., Woelken, L., Rauh, C., & Kurreck, J.
Int J Mol Sci. 2024 Feb 2;25(3):1811
PMID: 38339088 PMCID: PMC10855587 DOI: 10.3390/ijms25031811

Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells.
Urzi, A., Lahmann, I., Nguyen, L. V. N., Rost, B. R., García-Pérez, A., Lelievre, N., Merritt-Garza, M. E., Phan, H. C., Bassell, G. J., Rossoll, W., Diecke, S., Kunz, S., Schmitz, D., & Gouti, M.
Nat Commun. 2023;14(1):8043. Published 2023 Dec 19.
PMID: 38114482 PMCID: PMC10730704 DOI: 10.1038/s41467-023-43781-3

Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages.
Lin M, Sigal M.
Signal Transduct Target Ther. 2023 Nov 6
PMID: 37926715 PMCID: PMC10625954 DOI: 10.1038/s41392-023-01677-0

Mucosa-associated microbiota alterations in primary sclerosing cholangitis (PSC) before and after liver transplantation-who is calling the shots?
Lin, M., & Sigal, M.
Hepatobiliary surgery and nutrition, 2023 Oct 1
PMID: 37886186 PMCID: PMC10598306 DOI: 10.21037/hbsn-23-335

Association of Helicobacter pylori Positivity With Risk of Disease and Mortality
Wizenty, J., Koop, P. H., Clusmann, J., Tacke, F., Trautwein, C., Schneider, K. M., Sigal, M., & Schneider, C. V.
Clinical and translational gastroenterology, 2023 Sept. 1
PMID: 37367296 DOI: 10.14309/ctg.0000000000000610

Ex vivo infection model for Francisella using human lung tissue
Köppen K, Fatykhova D, Holland G, Rauch J, Tappe D, Graff M, Rydzewski K, Hocke AC, Hippenstiel S, Heuner K.
Front Cell Infect Microbiol. 2023 Jul 10
PMID: 37492528 DOI: 10.3389/fcimb.2023.1224356

Mapping strategies towards improved external validity in preclinical translational research.
Carneiro CFD, Drude N, Hülsemann M, Collazo A, Toelch U.
Expert Opin Drug Discov. 2023; 1-13.
PMID:37691294 DOI: 10.1080/17460441.2023.2251886

A Critical Study on Acylating and Covalent Reversible Fragment Inhibitors of SARS-CoV-2 Main Protease Targeting the S1 Site with Pyridine.
Wamser R, Pach S, Arkona C, Baumgardt M, Aziz UBA, Hocke AC, Wolber G, Rademann J. A.
ChemMedChem. 2023
PMID: 36812048 DOI: 10.1002/cmdc.202200635

Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Nouailles G, Adler JM, Pennitz P, Peidli S, Teixeira Alves LG, Baumgardt M, Bushe J, Voss A, Langenhagen A, Langner C, Martin Vidal R, Pott F, Kazmierski J, Ebenig A, Lange MV, Mühlebach MD, Goekeri C, Simmons S, Xing N, Abdelgawad A, Herwig S, Cichon G, Niemeyer D, Drosten C, Goffinet C, Landthaler M, Blüthgen N, Wu H, Witzenrath M, Gruber AD, Praktiknjo SD, Osterrieder N, Wyler E, Kunec D, Trimpert J.
Nat Microbiol. 2023 May.
PMID: 37012419 DOI: 10.1038/s41564-023-01352-8

Unwelcome guests - the role of gland-associated Helicobacter pylori infection in gastric carcinogenesis.
Beccaceci G, Sigal M.
Frontiers in Oncology 2023;13:1171003. Published 2023 Apr 21.
DOI:10.3389/fonc.2023.1171003

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.
Lin M, Hartl K, Heuberger J, Beccaceci G, Berger H, Li H, Liu L, Müllerke S, Conrad T, Heymann F, Woehler A, Tacke F, Rajewsky N, Sigal M.
Nat Commun. 2023;14(1):3025. Published 2023 May 25.
PMID: 37230989 DOI: 10.1038/s41467-023-38780-3

Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo.
Parshad B, Schlecht MN, Baumgardt M, Ludwig K, Nie C, Rimondi A, Hönzke K, Angioletti-Uberti S, Khatri V, Schneider P, Herrmann A, Haag R, Hocke AC, Wolff T, Bhatia S.
Nano Lett. 2023;23(11):4844-4853.
PMID: 37220024 DOI: 10.1021/acs.nanolett.3c00408

Generation of a Perfusable 3D Lung Cancer Model by Digital Light Processing.
Mei Y, Wu D, Berg J, Tolksdorf B, Roehrs V, Kurreck A, Hiller T, Kurreck J.
International Journal of Molecular Sciences. 2023; 24(7):6071.
DOI: 10.3390/ijms24076071

Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L.
Antiviral Res. 2023 Jan;209:105475.
PMID: 36423831 DOI: 10.1016/j.antiviral.2022.105475

State-of-the-art analytical methods of viral infections in human lung organoids.
Baumgardt M, Hülsemann M, Löwa A, Fatykhova D, Hoffmann K, Kessler M, Mieth M, Hellwig K, Frey D, Langenhagen A, Voss A, Obermayer B, Wyler E, Dökel S, Gruber AD, Tölch U, Hippenstiel S, Hocke AC, Hönzke K.
PLoS One. 2022 Dec 20;17(12):e0276115.
PMID: 36538516 DOI: 10.1371/journal.pone.0276115

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus.
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC.
Sci Rep. 2022 Nov 29;12(1):20608.
PMID: 36446841 DOI: 10.1038/s41598-022-24792-4

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C.
PLoS Biol. 2022 Nov 16;20(11):e3001871.
PMID: 36383605 DOI: 10.1371/journal.pbio.3001871

R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.
Fischer AS, Müllerke S, Arnold A, Heuberger J, Berger H, Lin M, Mollenkopf HJ, Wizenty J, Horst D, Tacke F, Sigal M.
J Clin Invest. 2022;132(21):e151363. Published 2022 Nov 1.
PMID: 36099044 DOI:10.1172/JCI151363

Once upon a dish: the next frontier in engineering multicellular systems.
Huch M, Gouti M.
Development. 2022 Oct 15;149(20):dev200744.
PMID: 36255367 DOI: 10.1242/dev.200744

Reinventing the Penumbra - the Emerging Clockwork of a Multi-modal Mechanistic Paradigm.
Walther J, Kirsch EM, Hellwig L, Schmerbeck SS, Holloway PM, Buchan AM, Mergenthaler P.
Transl Stroke Res. 2022 Oct 11.
PMID: 36219377 DOI: 10.1007/s12975-022-01090-9

Evaluating the Suitability of 3D Bioprinted Samples for Experimental Radiotherapy: A Pilot Study.
Al-Zeer MA, Prehn F, Fiedler S, Lienert U, Krisch M, Berg J, Kurreck J, Hildebrandt G, Schültke, E.
Int J Mol Sci. 2022 Sep 1;23(17):9951.
PMID: 36077349 DOI: 10.3390/ijms23179951

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Commun Biol. 2022 Aug 25;5(1):875.
PMID: 36008580 DOI: 10.1038/s42003-022-03828-5

Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research.
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
EMBO Rep. 2022 Aug 3;23(8):e55095.
PMID: 35876564 DOI: 10.15252/embr.20225509

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics.
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
Eur Respir Rev. 2022 Jul 27;31(165):220056.
PMID: 35896273 DOI: 10.1183/16000617.0056-2022

Hamster models of COVID-19 pneumonia reviewed: How human can they be?
Gruber AD, Firsching TC, Trimpert J, Dietert K.
Vet Pathol. 2022 Jul;59(4):528-545.
PMID: 34856819 DOI: 10.1177/03009858211057197

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
Wizenty J, Müllerke S, Kolesnichenko M, Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F, Sigal M.
EMBO J. 2022, June 29; 41(13):e109996.
PMID: 35767364 DOI:10.15252/embj.2021109996

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.
Eur Respir J. 2022 Jun 21:2102725.
PMID: 35728978 DOI: 10.1183/13993003.02725-2021

A Systematic Scoping Review on 3D Printing Technologies of Liver Organ Models.
Huelsemann M, Ali A S M , Berg J, Bannach-Brown A, Dressler C, Dhamrait D, Khankeh S, Toelch U, Braeuning A, Kurreck J.
2022, June 3
DOI: 10.17605/OSF.IO/WMY3X

High Performing Additively Manufactured Bone Scaffolds Based on Copper Substituted Diopside.
Pang S, Kamutzki F, Kurreck J, Gurlo A, Hanaor D.
Materials & Design. 2022 Mar; 215:110480.
DOI: 10.1016/j.matdes.2022.110480

The Rise of Three Rs Centres and Platforms in Europe.
Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandström J, Ragan I, Bubalo N, Spielmann H.
Altern Lab Anim. 2022 Mar;50(2):90-120.
PMID: 35578444 DOI: 10.1177/02611929221099165

Einstein Center 3R in Berlin.
Hippenstiel S, Thöne-Reineke C, Kurreck J.
Corners, ALTEX - Alternatives to animal experimentation, 39(1), 2022 pp. 161–171.
Available at: https://www.altex.org/index.php/altex/article/view/241

Stem Cells, Helicobacter pylori and Mutational Landscape - Utility of Pre-Clinical Models to Understand Carcinogenesis and to direct Management of Gastric Cancer.
Liabeuf D, Oshima M, Stange DE, Sigal M.
Gastroenterology. 2022 Apr;162(4):1067-1087 Nature. 2021 Dec;600(7887):37.
PMID: 34942172 DOI: 10.1053/j.gastro.2021.12.252

Animal experiments: EU is pushing to find substitutes fast.
Hippenstiel S, Thöne-Reineke C, Kurreck J.
Nature. 2021 Dec;600(7887):37.
PMID: 34848864 DOI: 10.1038/d41586-021-03539-7

Bioprinted Cancer Model of Neuroblastoma in a Renal Microenvironment as an Efficiently Applicable Drug Testing Platform.
Wu D, Berg J, Arlt B, Röhrs V, Al-Zeer MA, Deubzer HE, Kurreck J.
Int J Mol Sci. 2021 Dec 23;23(1):122.
PMID: 35008547 DOI: 10.3390/ijms23010122

Bioprinted Multi-Cell Type Lung Model for the Study of Viral Inhibitors.
Berg J, Weber Z, Fechler-Bitteti M, Hocke AC, Hippenstiel S, Elomaa L, Weinhart M, Kurreck J.
Viruses. 2021 Aug 11;13(8):1590.
PMID: 34452455 DOI: 10.3390/v13081590

A systematic review on the contribution of organ models to COVID-19 research.
Hülsemann M, Kniffert S, Drude N I, Bannach-Brown A, Tölch U, Hippenstiel S, Hocke A C.
PROSPERO 2021 CRD42021250999
Available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021250999